Molybdenum is essential for the industrial use as a molybdenum wire as well as for our body. Approximately 0.07 mg of molybdenum per kilogram of weight is present in our body. In the liver and kidneys molybdenum is highly concentrated and in the vertebrae molybdenum is low concentrated. Human tooth enamel also consists of molybdenum because to reduce tooth enamel decay it is very helpful. Molybdenum content of food helps to find out the variation in the mean daily ingestion of molybdenum. Usually the variation lies between 0.12 and 0.24 mg.
The considerable nutritional sources of molybdenum are eggs, green beans sunflower seeds, lentils, cucumbers, wheat flour and muesli granules etc. however pork, lamb and beef liver every one consists of about 1.5 parts per million of molybdenum. Since lethality of molybdenum is occurred mainly due to chemical state hence keen lethality has not been observed in human beings. However the harm of molybdenum is not practically accessible yet according to animal studies diseases like diarrhea, decreasing rate of growth, low birth weight, sterility and gout occur when the more than 10 mg/day of molybdenum is chronically eaten. Molybdenum also has a harmful effect on lungs, liver and kidney. To overcome from the harms of molybdenum, sodium tungsten is considered as a solution. It is also called as the competitive inhibitor of molybdenum since concentration of molybdenum is decreased by nutritional tungsten in tissues.
It is observed that increasing speed of esophageal cancer from northern china to Iran in a geological group is due to the dietetic molybdenum lack as of low soil concentration of molybdenum. Where as in United States where the soil has huge supply of it, people have 16 times superior danger protected for esophageal squamous cell carcinoma which exist in these area.
However the lack of molybdenum is also observed as an outcome of non-molybdenum added entire parenteral nourishment or complete intravenous nourishment for an extensive moment stage. That fallout the increase in blood points of sulfite and urate, mostly in the equal path like molybdenum cofactor insufficiency.It is observed that mature has maximum probability of having pure molybdenum shortage due to this system; the neurological significances have not been termed as for the hereditary cofactor shortage.
Sulfite oxidase, xanthine oxidoreductase, aldehyde oxidase and mitochondrial amidoxime reductase are the four enzymes in human beings that depend on molybdenum. Humans that have harshly shortage of molybdenum suffer with bad working of sulfite oxidase and are prepared for the harmful reactions to sulfites in foodstuffs. The obstruction with the capability of the body to apply molybdenum in enzymes causes a hereditary molybdenum cofactor shortage ailment. That originate the increase in sulfite levels and urate levels also the neurological hurt. A heterocyclic molecule which is present in all human enzymes that apply molybdenum, unites molybdenum on its energetic locations, due to this human body becomes unable to produce molybdenum cofactor.
Copper shortage in human body is formed due to the obstruction of increasing levels of molybdenum with body's uptake of copper. From the combination of copper, plasma proteins are escaped with the help of molybdenum.
Besides of significance of molybdenum in the human body, this element is widely used in the industrial scale in its various forms like molybdenum wire, sheet, rod and others.